Angina kezelés során a diabetes, Magyar Diabetes Társaság On-line
Tartalom
This is not a simple consequence of atherosclerosis developing more frequently and earlier as well as in a more severe form in diabetes. The decrease in the capacity of oxygen delivery contributes also to this phenomenon as a consequence of enhanced glycation of haemoglobin in the erythrocytes.
Furthermore, the development of microangiopathy in cerebral and coronary vessels may aggravate hypoxia and ischaemia in these organs, and the energy-wasting as well as more oxygen-requiring metabolic processes may develop following the step by step denervation of the heart due to cardiovascular autonomic diabetic neuropathy.
High doses of benfotiamin could moderate the evolvement of diabetic autonomic neuropathy, and the new piperazidine derivative, trimetazidine provides a fundamentally new method in the cardioprotection.
The direct cardioprotective effect of trimetazidine was demonstrated in angina pectoris, in myocardial infarction as well as during PTCA and open heart surgery.
Kérem várjon! A szív egészsége és a cukorbetegség Szívbetegség és sztrók A szívroham és a sztrók tünetei A szívroham és a sztrók kezelése A szívbetegség és a sztrók megelőzése A szervezet minden részének állandó oxigénellátásra van szüksége ahhoz, hogy jól működjön, különösen igaz ez a szívre és az agyra. Az oxigénben gazdag vér a verőerek artériák kiterjedt hálózatán keresztül áramlik szét a testben.
Our preliminarz observations indicate that the cardioprotective, antianginal effect of trimetazidine could be observed only in diabetic patients with good metabolic control. The Firmingham study. JAMA Brit Med J 3: Diabetes Vaisrub, S: The autonomous heart in diabetic autonomic neuropathy.
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Adv Exp Biol Med J Cardiovasc Surg Eur Heart J Eu Heart J Eur J Clin Pharmacol Clin Pharmac Am J Cardiol 8BB, Curr Therap Res Michaelides, AP, Spiropoulos, K, Dimopoulos, K, Athanasiades, D, Toutouzas, P: Antianginal efficacy of the combination of trimetazidine-propranolol compared with isosorbide dinitrate-propranolol in patients with stable angina.
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Heart Cardioscan 3. Suppl A : ,
