Diabetes and heart disease ppt. Hypertonia ©s diabetes kr³nikus vesebetegs©gben

Az előadások a következő témára: "Cardiovascularis kockázatcsökkentés a diabetológus szemével"— Előadás másolata: 1 Cardiovascularis kockázatcsökkentés a diabetológus szemével Balatonaliga, május The Verona Diabetes Complications Study showed that, in diabetic and non-diabetic subjects, insulin resistance is associated with several cardiovascular risk factors, including hyperglycaemia, dyslipidaemia and hypertension.

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The study identified insulin resistance as an independent risk factor for cardiovascular disease. HDL cholesterol concentrations are increased and there is a preponderence of small dense, atherogenic, LDL particles in patients. PAI-1 plasminogen activator inhibitor-1 : PAI-1 is a major regulator of plasminogen activation and plays an important role in blood clotting.

PAI-1 concentrations are increased in patients with type 2 diabetes. BPH benign prostatic hyperplasia : BPH is a disease that involves the enlargement of the prostate, particularly in elderly men.

They are major risk factors for the developmentand progression of endothelial dysfunction and atherosclerosis,and contribute to the progression of renal failure—yetthese patients tend to be less intensely treated than patientswith normal renal function. Inflammatory mediators and promotersof calcification are increased and inhibitors of calcification arereduced in CKD, which favours vascular calcification and vascularinjury. Microalbuminuria increases cardiovascular risk two- tofour-fold. In a large cohort study, anaemia,decreased GFR, and microalbuminuria were independently associatedwith CVD and, when all were present, CVD was commonand survival was reduced.

There is a strong association between insulin resistance and BPH. It is now known to exert a variety of catabolic effects which may impair cellular insulin action, increase lipolysis and inhibit glucose transporter 4 GLUT4 expression. MCP-1 monocyte chemotactic protein-1 : MCP-1 is involved in inflammation by mediating the migration of monocytes and T-cells into inflammatory sites. MMP-9 matrix metalloproteinase-9 : Matrix metalloproteinases are a family of membrane-bound zinc-endopeptidases that can degrade all of the components of the extracellular matrix and are implicated in the pathology of atherosclerotic plaque rupture.

MMP-9 concentrations are raised in type 2 diabetes and may confer an increased risk of atherosclerotic disease. References 1.

PPT - Hypertonia és diabetes krónikus vesebetegségben PowerPoint Presentation - ID

Bonora E, et al. Diabetes Care ; 2.

Drugs ; 58 Suppl 1 Laakso M. Int J Clin Pract Suppl ; Over the follow-up period, diabetes and heart disease ppt experienced and incident cardiovascular event heart attack, stroke, heart surgery, angina, or CVD death.

Reference Hanley AJ et al. Diabetes Care ; 16 Klinikai kórformák Inzulinrezisztencia Hyperinsulinaemia 17 Causes of mortality in diabetic patients Myocardial infarction These are therefore the three main targets for therapeutic intervention.

Antihypertensive and lipid-lowering treatments are important, but are outside the scope of this presentation. We will concentrate on a review of the evidence demonstrating that the choice of antidiabetic therapy and choice of treatment approach for managing hyperglycaemia have significant influence in reducing morbidity and mortality in type 2 diabetes.

The Lancet UKPDS is the longest and largest prospective randomised controlled trial dedicated to a study of type 2 diabetics ever carried out. The study, managed from Oxford but conducted in 23 centres around the UK is also a rich source of epidemiology data on the natural history of diabetes.

Lancet HbA1C increased steadily with time in the conventional treatment arm.

Hypertonia ©s diabetes kr³nikus vesebetegs©gben - [PPT Powerpoint]

The intensive glucose control regimen induced an initial fall in HbA1C over the first year, after which this parameter also increased at a similar rate.

Intensive therapy achieved significantly lower HbA1C values throughout the study, with a median a cukorbetegség napraforgó kezelése of 0. However, intensive treatment based primarily on a monotherapy approach, did not maintain optimal glycaemic control reflecting the progressive nature of type 2 diabetes.

Lancet ;— Intenzív 7.

Cardiovascularis kockázatcsökkentés a diabetológus szemével

Kardiovaszkuláris és összmortalitás 32 Hyperglykaemia és szövődmények Improving the Prognosis of Patients diabetes and heart disease ppt Type 2 Diabetes Slide In addition, the risk of microvascular complications increases markedly as HbA1C rises. Management approaches which achieve near normal glycaemic control are likely to have the biggest impact in reducing the incidence of heart attacks.

Diabetes Care Carey DG. Obesity Res ; — Lebovitz H, et al. J Clin Endocrinol Metab ; — St John Sutton M, et al.

• Az előadások a következő témára: "A hagyományos kardiovaszkuláris rizikófaktorok és a diabetes"— Előadás másolata: 1 A hagyományos kardiovaszkuláris rizikófaktorok és a diabetes microvascularis szövődményeinek összefüggése Prof.
• Kiss István.
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Diabetes Care ; — Cobitz A, et al. DALM Abstract and poster. Data on file.

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Freed MI. Am J Cardiol ; — Bakris G, et al. J Hum Hypertens ; — Natali A, et al.

Diabetes ; 51 Suppl. Freed M, et al. Diabetologia ; 43 Suppl.