Type 1 diabetes 2021 bmj. Appendix 1. Programme Evaluation Citations - BMJ Global Health - kapcsolódó dokumentumok
Specifically, those participants who took higher doses of statins were 34 percent more likely to be hospitalized for acute kidney injury during the first days of treatment, compared to their counterparts who were taking lower doses.
This risk remained elevated two years after starting treatment. The findings appeared online March 19 in the journal BMJ. Statins are widely prescribed to lower blood cholesterol levels, and can be very effective.
They do, however, confer their share of risks, most notably liver damage and muscle pain or weakness. Doctors currently recommend that people take a liver enzyme test before or shortly after they type 1 diabetes 2021 bmj taking statins.
The issue of kidney damage as seen in the current study, however, is relatively new. Canadian researchers analyzed the health records from more than 2 million people aged 40 or older with or without kidney disease who were also taking statins. High-dose statins included rosuvastatin Crestor at doses of 10 milligrams mg or higher, atorvastatin Lipitor at doses of 20 mg or higher and simvastatin Zocor at doses of 40 mg.
All other statin doses were considered low dose.
People with kidney disease were not at higher risk for acute kidney problems independent of their statin use, the study found. To illustrate the effect of statin dosage, about 1, people without kidney disease would need to be treated with a high-dose statin rather than a low-dose version to cause one additional hospitalization for kidney injury, the researchers said. Exactly how -- or even if -- statins cause kidney injury is not known.
In addition, statins have been shown to block the production of coenzyme Q10 a substance in the body that helps break down foodwhich could theoretically lead to kidney injury, he said.
Dormuth said that other studies have shown a link between statin treatment and protein in the urine, which is a hallmark of kidney disease. There are both urine and blood tests your doctor can use to monitor your kidneys.
Have a conversation with your doctor diabetes terhes betegek discuss your benefits and risks, and ask if your kidney function has been tested. The study is observational, but randomized controlled trials, which are considered the gold standard of research, do not show any uptick in kidney injury among people who take statins, said Dr.
Although the results are surprising, Bangalore said, the reason behind them may have more to do with why these individuals needed such high doses of the statins in the first place.
More information Learn more about kidney disease at the U. National Institutes of Health.